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In recent years, oligopeptide-1 has emerged as a standout ingredient in the cosmetics industry. This highly active skincare component has gained significant attention, appearing in numerous high-end formulations. But what exactly makes it so popular and effective?   What is Oligopeptide-1?   Oligopeptide-1, also called as tripeptide-1, is a small molecule composed of three amino acids, designed to mimic the body’s natural signaling peptides. Its unique structure allows it to penetrate deep into the skin and “communicate” with skin cells, activating repair and regeneration mechanisms.     The Key Benefits of Oligopeptide-1   Oligopeptide-1 has become a sought-after ingredient thanks to its wide-ranging skincare benefits:   Boosts Collagen Production As we age, collagen levels in the skin decline, leading to wrinkles and loss of elasticity. Oligopeptide-1 stimulates fibroblasts to produce collagen, helping to firm the skin and reduce fine lines.   Repairs the Skin Barrier It strengthens the skin’s natural barrier, improving resilience and protecting against environmental damage. This makes it especially beneficial for sensitive skin.   Accelerates Skin Healing Mimicking the effects of growth factors, oligopeptide-1 promotes faster cell turnover and repair, making it effective for reducing acne scars and addressing damaged skin.   Antioxidant and Anti-Inflammatory Properties Oligopeptide-1 combats free radical damage while soothing inflammation, helping maintain a calm and healthy complexion.   Why Are More People Choosing Products with Oligopeptide-1 ?   Effective Yet Gentle: Oligopeptide-1 works in harmony with the skin’s natural processes and is non-irritating, making it suitable for all skin types, including sensitive skin.   Backed by Science: Research has demonstrated that oligopeptide-1 significantly increases collagen production and improves skin quality, earning it credibility in the skincare world.     Versatile Benefits: Beyond anti-aging, it addresses multiple skin concerns, offering a comprehensive approach to skincare.     Oligopeptide-1 has become a favorite in the cosmetics industry due to its exceptional anti-aging, repair, and protective properties. It not only helps maintain youthful-looking skin but also addresses a variety of skin concerns. With its versatility and effectiveness, it’s no wonder oligopeptide-1 is celebrated as a powerhouse ingredient. Adding a product with oligopeptide-1 to your skincare routine could be your next step toward healthier, more radiant skin!   If you are interested in our products and want to know more details, please contact judyzhou@drop-bio.com.

  Small-molecule peptides have become a trending ingredient in skincare, often touted for their anti-aging benefits. But do they truly live up to the hype when it comes to reducing wrinkles? Let’s explore the science behind their effectiveness.   What Are Small-Molecule Peptides?   Small-molecule peptides are short chains of 2–10 amino acids with low molecular weight, making them easy to absorb through the skin. Once they penetrate the skin barrier, they act directly on the dermis. Common types include tetrapeptides, hexapeptides, and copper peptides, known for stimulating collagen production, enhancing skin elasticity, and providing antioxidant protection.   How Do They Work Against Wrinkles?   1.Stimulating Collagen Production Collagen loss is a key factor in wrinkle formation. Small-molecule peptides activate fibroblasts, boosting collagen synthesis to improve skin firmness and reduce fine lines and wrinkles.   2.Antioxidant Protection Free radicals can damage skin cells and accelerate aging. Small-molecule peptides have antioxidant properties that neutralize free radicals, reducing oxidative stress from UV exposure and pollution.   3.Relaxing Facial Muscles Some peptides, like hexapeptides, block nerve signals to relax facial muscles, effectively softening expression lines such as crow’s feet and forehead wrinkles.   Is There Scientific Evidence?   Studies show that consistent use of peptide-infused skincare products can visibly improve skin elasticity and smoothness within weeks. For instance, 0.1% tetrapeptide-1(0.1mg/mL DropPet® TR-1P) has a collagen-promoting effect, which has been found to significantly reduce crow’s feet and nasolabial folds. However, the effectiveness depends on factors like peptide concentration, formulation, and absorption. Poorly designed products may fail to deliver the desired results.     How to Choose Skincare with Small-Molecule Peptides?   1.Check the Ingredients: Look for clearly labeled peptides like tetrapeptides, hexapeptides, or copper peptides.   2.Prioritize Concentration: Higher peptide concentrations typically yield better results.   3.Be Consistent: Long-term use, combined with good skincare habits like sun protection and hydration, enhances effectiveness.   Conclusion   Small-molecule peptides show promising results in reducing wrinkles, particularly by stimulating collagen production and combating oxidative stress. While they’re not a “magic cure,” they are a valuable tool for slowing down the signs of aging. With the right product and consistent use, small-molecule peptides could become your go-to ally in the fight against wrinkles.     Your skin is in a race against time—small-molecule peptides might just be the secret to staying ahead!   If you are interested in our products and want to know more details, please contact judyzhou@drop-bio.com.

Surfactants, classified under the “catalysts and various auxiliaries” branch of the fine chemicals industry, are an indispensable part of modern production. Often referred to as the “MSG of the industrial world,” they find applications across virtually all fine chemical sectors, including industrial processes, agriculture, personal care, and new material development.   In recent years, personal care and cleaning products have become two of the most significant global consumer markets. Surfactants are key ingredients in these products and are among the substances that come into frequent contact with the skin. Depending on their hydrophilic-lipophilic balance (HLB) value, surfactants can serve multiple functions, such as cleaning, foaming, emulsifying, wetting, dispersing, and solubilizing.   However, many widely used surfactants, such as alkyl sulfonates and alkyl sulfates, are directly applied to the skin in rinse-off personal care products like shampoos and body washes. These compounds may cause skin irritation and allergic reactions, raising concerns about their safety.   Sophorolipids: A Safer, Eco-Friendly Alternative     Sophorolipids, a class of glycolipid biosurfactants produced by yeast fermentation, have gained attention for their unique properties. They are non-toxic, biodegradable, and environmentally friendly, making them one of the most promising natural surfactants with significant market potential.   Sophorolipids provide multiple benefits, including:   Functional Advantages: Effective at dispersing, wetting, retaining moisture, lubricating, and emulsifying. Mild surfactant properties suitable for sensitive applications. Gentle antibacterial effects, efficiently inhibiting Propionibacterium acnes and Lactobacillus. Anti-inflammatory activity, reducing the release of inflammatory cytokines. Inhibition of lipase activity, preventing the breakdown of sebum into free fatty acids.   Skin Benefits: Stimulates dermal fibroblast metabolism and promotes collagen synthesis. Neutralizes free radicals and inhibits elastase activity, enhancing skin elasticity and repair. Activates macrophages and supports fibrinolytic functions.   Environmental and Safety Features: Heat-resistant and stable across a wide pH range. Safe and non-toxic with no irritation to the skin. Fully biodegradable and environmentally sustainable.   Growing Market Adoption   Due to their exceptional performance and safety profile, sophorolipids have already been adopted by leading international brands in personal care and cosmetic products. These end-use products are now widely available in markets across the EU, the US, Japan, and China.

Adenosine is a common active ingredient in skincare products, valued for its potential anti-aging and skin-repairing properties. Here are some of the key benefits of adenosine for the skin: Adenosine boosts the energy metabolism of skin cells and stimulates collagen production, which helps to smooth fine lines and wrinkles while improving skin elasticity and firmness.It also strengthens the skin barrier, contributing to a smoother and healthier complexion. Adenosine has anti-inflammatory properties that can soothe sensitive skin and reduce redness and irritation caused by inflammation. Adenosine stimulates microcirculation in the skin, improving dullness and making skin look more radiant and healthy. Adenosine is often considered a gentle active ingredient for all skin types, including sensitive skin. Precautions： The concentration of adenosine in skincare products is generally low (0.1%-1%), which is sufficient to be effective without irritating the skin. Adenosine can work synergistically with other anti-aging ingredients (e.g., niacinamide, vitamin C), but avoid using it together with ingredients that may cause irritation (e.g., high concentrations of fruit acids).

Sensitive skin often struggles with redness, irritation, and an impaired skin barrier, making it prone to discomfort and inflammation. Vitamin B12 (cobalamin), has emerged as an ideal ingredient for soothing and restoring sensitive skin due to its unique anti-inflammatory and reparative properties. One of the highlights of Vitamin B12 is its excellent anti-inflammatory effects. Dermatitis symptom scores decreased significantly more on the side treated with VB12 cream than on the side treated with blank cream. By reducing the level of inflammation, Vitamin B12 relieves redness and irritation, providing an immediate soothing effect on damaged skin. In addition, vitamin B12 plays a key role in repairing the skin barrier. It promotes protein synthesis, particularly the production of keratin and collagen, which are essential for maintaining the skin's protective layer. A strengthened barrier not only helps lock in moisture, but also protects against external stimuli, thus making the skin less sensitive. Vitamin B12 also possesses powerful antioxidant properties that neutralize free radicals and reduce oxidative stress caused by environmental factors such as UV rays and pollution. This protective effect further reduces the feeling of skin irritation and supports skin health. There are three different specifications of DropCare® VB12 availabled to customers. Gentle and highly effective, Vitamin B12 brings significant improvement to sensitive skin through its multiple actions of soothing, repairing, and protecting, while enhancing the skin's resilience and comfort.

Mandelic acid is an alpha hydroxy acid (AHA) with a relatively large molecular structure, which means it penetrates the skin more slowly and is therefore considered gentler compared to other acids. Due to its lipophilic nature, mandelic acid is particularly suitable for oily and acne-prone skin. Its oil-regulating effects include the following: 1. Dissolving Oil in Pores: Mandelic acid can penetrate deep into the pores to help dissolve excess sebum, clearing out debris that clogs pores and reducing the formation of blackheads and acne. 2. Regulating Oil Secretion: By removing excess oil from the pores, mandelic acid gradually helps balance oil secretion, leaving the skin less shiny and with a fresher appearance. 3. Gentle Exfoliation: As a mild AHA, mandelic acid promotes the shedding of dead skin cells, making the skin smoother and more radiant. This gentle exfoliation helps prevent clogged pores caused by excess buildup.   In addition, mandelic acid has antibacterial and skin-brightening properties, making it suitable for regular use. When using mandelic acid, it’s recommended to introduce it gradually and always pair it with good sun protection to achieve optimal skincare benefits.

Retinoids are substances that are similar in structure and function to retinol, including: Drugs such as retinoic acid (RA), isotretinoin, adapalene, tazarotene, etc.; Retinol (retinol), retinaldehyde, retinyl palmitate, retinyl propionate, retinyl retinoate, and now the up-and-coming hydroxypinazone retinoate (HPR), among others. These substances can be converted into each other, so that there is a transformation pathway: After the body absorbs retinol, if it can't consume it, it converts it into retinyl palmitate and stores it, and when needed, hydrolyzes the palmitate bond with esterase (the red position in the retinol ester structure diagram on the right is broken), and retinol is released.Retinol is stripped of a hydrogen atom and oxidized to become retinaldehyde, which is an intermediate state. Retinaldehyde is further oxidized, adding an oxygen atom that becomes retinoic acid.Retinoic acid (tretinoin/retinoid) is the actual form of retinoid that enters the nucleus to bind to trans-retinoin reaction elements (RAR/RXR) and initiates the corresponding gene expression. It not only retains the efficacy group of tretinoin, but can directly bind to the receptor; It also covers the irritating groups and improves the physical and chemical stability. Cosmetics containing HPR (Hydroxypinacolone Retinoate)  can be used even on VA-sensitive skin, but note that pregnant women should not use them!        

A quick and easy way to get a healthy wheat-skin tone is to apply a tanning product. When selecting a tanning product, people tend to choose different products based on the degree of color they want to achieve. In fact, the main efficacy substance of most products is dihydroxyacetone(DHA). The dosage of dihydroxyacetone(DHA) added determines the final degree of coloration of the product on the skin. So what's the mechanism of dihydroxyacetone discoloration on the skin? Dihydroxyacetone and proteins in the skin undergo a Malanin reaction, turning the cuticle proteins brown.The specific reaction principle is as follows: Dihydroxyacetone(DHA) does not damage the skin, and is considered a safe skin coloring agent. The color is not removed by simple washing, swimming, or natural perspiration, but it only lasts for 5 to 7 days, as skin cells are continuously being shed. Exfoliation, tape stripping, prolonged water submersion, or heavy sweating can lighten the tan, as these all contribute to rapid dead skin cell pealing. Today, dihydroxyacetone(DHA) is the main active ingredient in virtually all sunless tanning skincare preparations. The above pictures were taken from some subjects in a clinical experiment of DropBio. The coloring was recorded after 3 consecutive times (once a day) of using Instant Tanning Mousse with 10% DropBio@ DHA, and the subsequent fading was continuously recorded. So Dihydroxyacetone(DHA) is a very effective ingredient for self-tanning.  

As we all know, ceramide is a lipid that is similar in structure to the substance that makes up the cuticle of the skin, so it can quickly penetrate the skin and maintain the renewal of the skin's natural protective layer, maintain the balance of natural hydration. When combined with the moisture in the cuticle, it can form a net-like structure to firmly lock the moisture. Ceramide is an important skin-activating ingredient in the cuticle that strengthens the skin barrier, rebuilds cells, and reduces the effects of the external environment by forming effective skin surface barriers.      When Ceramide is added to the damaged skin, the composition of the lipids between the cells is improved and the cells on the surface of the skin become compact and regular again.While the moisture inside the skin is locked in, the outside irritation and bacteria can no longer penetrate the skin's surface, effectively reducing sensitivity and acne formation, so Ceramide is a safe, natural and highly effective skin care ingredient.

In the world of hair care, combating hair loss and promoting robust hair growth requires innovative, scientifically formulated ingredients. DropCare® DO (Diaminopyrimidine Oxide) is a cutting-edge active ingredient designed to address the root causes of hair thinning and loss, making it an ideal choice for modern hair care formulations. What is DropCare® DO? DropCare® DO is a powerful hair care active with the INCI name Diaminopyrimidine Oxide. It is specifically developed to: Inhibit hair loss Promote hair growth By targeting key biological processes within the hair follicle, DropCare® DO helps restore hair vitality and support continuous healthy growth. How Does DropCare® DO Work? Hair loss, particularly androgenetic alopecia (AGA), is often driven by hormonal factors and oxidative stress, leading to follicle miniaturization and fibrosis. DropCare® DO acts through a dual mechanism: Inhibition of 5α-ReductaseDropCare® DO reduces the conversion of testosterone to dihydrotestosterone (DHT), a key hormone responsible for follicle shrinkage and hair thinning in AGA. Anti-Fibrotic ActionBy inhibiting lysyl hydroxylase—an enzyme involved in collagen maturation—DropCare® DO helps soften hardened collagen around hair follicles. This reduces fibrosis, improves nutrient supply to the hair bulb, and prevents premature hair root degradation. Why Choose DropCare® DO Over Traditional Treatments? While treatments like minoxidil are commonly used, they often come with side effects such as skin irritation, allergic reactions, and restrictions for cosmetic use. DropCare® DO offers a safer, cosmetic-friendly alternative with proven efficacy and minimal risk of adverse effects. Key Benefits at a Glance ✅ Reduces DHT production by inhibiting 5α-reductase ✅ Softens collagen deposits around follicles to prevent hardening ✅ Revitalizes hair roots and extends the hair growth cycle ✅ Suitable for use in anti-hair loss and lash-enhancing products ✅ Safe, soluble, and stable in cosmetic formulations Application & Formulation Guidance Recommended Use: Anti-hair loss, hair strengthening, and eyelash growth formulations Recommended Inclusion: 0.5–1.5% Solubility: Compatible with water, 1,2-propanediol, 1,3-butanediol, and 1,2-pentanediol Stability: Optimal at pH ~5.5; may precipitate outside this range at concentrations >1.5% Product Specifications     Parameter Specification Appearance White to off-white powder Odor Characteristic Water (KF) 12–14% Turbidity < 10 FNU Purity (HPLC) ≥ 98.0% Conclusion DropCare® DO represents a new generation of hair actives—rooted in science, designed for performance, and safe for daily use. Whether you're developing a serum, shampoo, or conditioner, this ingredient offers a reliable and effective solution for consumers seeking to restore and maintain healthy hair. Ideal for: Anti-hair loss shampoos & treatments Eyelash growth serums Scalp care and revitalizing products Formulate with Confidence. Formulate with DropCare® DO. If you are interested in our products and want to know more details, please contact judyzhou@drop-bio.com.

In the relentless pursuit of youthful, firm, and radiant skin, cosmetic chemists are constantly seeking high-performance active ingredients that deliver visible, proven results. Meet DropPet® M3000, a powerful synergistic blend of two renowned peptides designed to fight wrinkles at their source and recreate the stereoscopic contours of the face. A Synergistic Powerhouse of Peptides At the heart of DropPet® M3000 lies a precise combination of two bio-mimetic peptides: Palmitoyl Tripeptide-1 (Pal-GHK): A cellular communicator known for its ability to stimulate the synthesis of key matrix macromolecules like collagen and glycosaminoglycans, effectively targeting and reducing the appearance of wrinkles. Palmitoyl Tetrapeptide-7 (Pal-GQPR): Works as an anti-inflammatory cellular messenger to support the skin's natural recovery process, stimulating collagen regeneration in the dermis and helping to restore a firmer, more resilient skin structure. Together, this dynamic duo works in harmony to provide a comprehensive anti-aging solution. Key Efficacy & Skin Benefits DropPet® M3000 offers a multi-faceted approach to skin rejuvenation: Firming & Renewal: Visibly tightens the skin and helps restore its youthful, three-dimensional contours. Boosts Matrix Synthesis: Promotes the skin's natural production of essential macromolecules—elastin, collagen, and hyaluronic acid. Increases Skin Thickness & Elasticity: By reinforcing the dermal structure, it leads to thicker, more supple, and resilient skin. Repairs the Skin Barrier: Strengthens the skin's natural defense system for healthier-looking skin. Deep Hydration: Helps increase the skin's hyaluronic acid content, attracting and binding moisture to the epidermis for a plumper, dewier complexion. Proven Clinical Results: See the Difference Data speaks louder than words. In a clinical study, 30 female volunteers aged 30-60 applied a cream containing 5% DropPet® M3000 to one side of their face (around the eyes and cheeks) for 8 weeks. The results, measured using the PRIMOS Lite system for precise wrinkle volume analysis, were significant: After 2 Weeks: A 15.7% improvement in total wrinkle volume. After 4 Weeks: A 21.7% improvement in total wrinkle volume. After 8 Weeks: A remarkable 30.2% reduction in total wrinkle volume. Statistical analysis confirmed that the improvement in the test group was significantly greater than in the control group (P < 0.05), validating the potent anti-wrinkle efficacy of DropPet® M3000. [Image: A graph showing the decreasing trend of wrinkle volume (ΔV) in the test group over 8 weeks.] Technical Profile & Application DropPet® M3000 is a versatile and stable ingredient, formulated for easy integration into your next high-performance skincare product. INCI Name: PALMITOYL TRIPEPTIDE-1 & PALMITOYL TETRAPEPTIDE-7 Appearance: Semitransparent viscous liquid Recommended Dosage: 3-5% Solubility: Disperses well in water (translucent solution). Ideal For: Anti-aging serums, creams, lotions, and high-end rejuvenating products. Storage: For optimal stability, store sealed in a cool place (2-8°C is best), protected from light. With its proven efficacy and compatibility, it's an ingredient worthy of brands like Elizabeth Arden, La Prairie, and CLINIQUE. Conclusion DropPet® M3000 is more than just a peptide blend; it's a scientifically-backed solution for significant skin rejuvenation. By effectively promoting the skin's natural repair and regeneration processes, it delivers on the promise of firmer, smoother, and more youthful-looking skin.   Ready to formulate the next generation of anti-aging cosmetics? Contact us today to learn more about incorporating DropPet® M3000 into your product line. If you are interested in our products and want to know more details, please contact judyzhou@drop-bio.com.

When it comes to lip care, consumers are looking for more than just hydration—they want visible results. That’s where DropPet® LipS (0.1%) and DropPet® LipS Hot (0.1%) come in. These innovative, peptide-based raw materials are specially formulated to address common lip concerns such as fine lines, loss of firmness, and uneven tone, while delivering a noticeable plumping effect. What Are DropPet® LipS and LipS Hot? Both products are ointment-style ingredients containing Palmitoyl Tripeptide-1, a well-studied signaling peptide known for its ability to support collagen and glycosaminoglycan synthesis. This helps improve skin thickness, elasticity, and overall lip structure. The key difference? DropPet® LipS Hot contains an additional natural thermal agent—Vanillyl Butyl Ether—which provides a gentle warming sensation upon application. This not only enhances the feeling of instant fullness but also promotes blood circulation, offering a soothing and pleasurable experience. Key Benefits: Lip Plumping: Reduces the appearance of fine lines and enhances lip volume. Fades Cheilogramma: Helps lighten dark or pigmented lips. Improves Lip Texture: Leaves lips softer, smoother, and more supple. Instant & Long-Term Results: LipS Hot offers immediate warmth and fullness, while both products support long-term lip rejuvenation. Backed by Science In vivo studies demonstrate that regular use of a lip balm containing DropPet® LipS (0.1%) significantly improves lip shape, softness, and protection. Volunteers reported: 100% improvement in lip shape 80% increase in lip softness 70% better lip protection Additionally, in vitro studies confirm that Palmitoyl Tripeptide-1 helps prevent collagen degradation caused by UVA exposure, supporting skin structure and resilience. Easy to Formulate These ingredients are oil-soluble and easily incorporated into: Lip balms Lip creams Lip masks Other lip care products Recommended Usage: 0.5%–5.0%Best Added: At 70–80°C during the final stages of production. Available Variants Both LipS and LipS Hot are available in two peptide concentrations: 0.1% and 0.01%, giving formulators flexibility based on desired potency and cost. Storage & Shelf Life Store in a dark place at room temperature (2–8°C recommended). Shelf life: 2 years. Whether you’re developing a luxury lip treatment or an everyday lip enhancer, DropPet® LipS and LipS Hot offer scientifically proven, customizable solutions for today’s beauty market. Interested in formulating with DropPet® LipS or LipS Hot?Contact us today for samples, technical data, or custom product options! If you are interested in our products and want to know more details, please contact judyzhou@drop-bio.com.