skinceuticals phloretin

In the ever-evolving world of skincare, consumers are increasingly seeking natural, effective, and safe ingredients. Meet DropBrigt® Phlor—a powerful plant-derived active that is revolutionizing cosmetic formulations with its exceptional multi-functional benefits. What is Phloretin? Phloretin is a natural dihydrochalcone flavonoid predominantly found in the peel and root bark of apples, pears, and other succulent fruits, as well as in plants like sweet tea and crabapple. Known for its strong antioxidant properties, phloretin has become a star ingredient in both cosmetics and functional foods. INCI Name: Phloretin CAS No.: 60-82-8 Molecular Formula: C₁₅H₁₄O₅ Key Benefits in Cosmetics 🌟 Skin Brightening & Whitening Phloretin effectively inhibits melanocyte activity and reduces the appearance of skin pigmentation and spots. Studies show that it outperforms well-known brightening agents like kojic acid and arbutin in tyrosinase inhibition. When combined with these agents, phloretin can achieve up to 100% inhibition—without the side effects. ✨ Antioxidant & Anti-Aging With an antioxidant capacity of 10.30 mg/L for lipid oxidation, phloretin neutralizes free radicals such as DPPH and ABTS, protects mitochondrial integrity, and delays skin aging. It helps maintain skin youthfulness and resilience against environmental stressors. 🔁 Anti-Inflammatory & Acne Care Phloretin soothes inflamed skin by blocking sugar penetration into epidermal cells, regulating sebum production, reducing COX-2 promoter activity, and inhibiting prostaglandin E2 synthesis. This makes it ideal for acne treatments and sensitive skin formulations. 💧 Transdermal Enhancement A safe and effective penetration enhancer, phloretin improves the absorption of other functional ingredients within cosmetic formulations, maximizing their efficacy—e.g., it significantly boosts the percutaneous absorption of Lidocaine HCl. 💆 Hair Loss Prevention By inhibiting soybean lipoxygenase (LOX), phloretin helps prevent premature hair aging and loss, making it a valuable addition to hair care products. Applications in Cosmetics Phloretin is widely used in a variety of skincare products, including: Whitening creams Repair serums Essences and toners Anti-aging treatments Acne solutions and soothing products Hair growth serums Leading global brands like SkinCeuticals have already incorporated phloretin into their bestselling products, recognizing its potent efficacy and consumer appeal. Safety & Regulations Phloretin is not only highly effective but also extremely safe: Oral LD₅₀: 5.760 g/kg (very low toxicity) Approved for use in cosmetics under China cosmetic ingredient code 02548 Complies with food additive standards (GB 1886.261-2016, GB2760 #N376) Recognized as GRAS by FEMA (#A390) and JECFA (#2022) Technical Specifications Indicator Specification Appearance Pearly white to light pink/yellow powder Odor Characteristic Assay ≥95.0% Melting Point 260–262°C Heavy Metals (Pb) ≤10 ppm Total Plate Count <1000 CFU/g Beyond Cosmetics: Food & Flavor Applications Phloretin also serves as a natural flavor modifier—especially useful in sugar-free or low-sugar food and beverage products. It masks bitterness, reduces off-notes from high-intensity sweeteners, and improves overall taste perception, often used in combination with stevia. Conclusion DropBrigt® Phlor is a versatile, evidence-based, and naturally derived active ingredient that meets the growing demand for safe and multifunctional components in cosmetics. Whether you’re developing serums, creams, toners, or haircare products, phloretin offers a compelling blend of efficacy, safety, and consumer trust. Enhance your formulations with DropBrigt® Phlor—where nature meets science. If you are interested in our products and want to know more details, please contact judyzhou@drop-bio.com.

In the quest for high-performance, multifunctional, and naturally-derived ingredients, the cosmetic and nutraceutical industries are constantly evolving. At the forefront of this innovation is DropBright® Phlor, a potent bioactive compound that bridges the gap between skincare science and holistic wellness. Sourced naturally from apple and pear tree bark, this remarkable ingredient from DropBio is redefining standards for efficacy and safety. What is DropBright® Phlor? DropBright® Phlor is a premium grade of Phloretin, a dihydrochalcone flavonoid known for its powerful antioxidant properties. With the INCI name Phloretin and CAS No. 60-82-2, it is a versatile molecule (C15H14O5) celebrated for its multi-targeted benefits. Recognized as safe by major global authorities—including China's cosmetic ingredient directory (No. 02548), JECFA, and FEMA GRAS (#4390)—its excellent safety profile is underscored by an extremely low oral toxicity (LD50 >5g/kg). A Multifaceted Powerhouse for Skin Health DropBright® Phlor's mechanism of action is as diverse as its benefits, making it a star ingredient in serums, creams, ampoules, and essences. Superior Skin Brightening & WhiteningDropBright®Phlor is a champion for achieving a radiant, even-toned complexion. It effectively inhibits tyrosinase activity—the key enzyme in melanin production—more potently than conventional agents like kojic acid and arbutin. Studies show that at 10 µg/mL, DropBright® Phlor achieves a 69.88% inhibition rate. When combined with other brighteners, it can work synergistically for enhanced results without the associated irritancy of some synthetic alternatives. Potent Antioxidant & Anti-Aging DefenderAs a robust antioxidant, DropBright® Phlor neutralizes free radicals generated by UV exposure and pollution. It protects skin lipids from peroxidation and helps preserve mitochondrial function in cells, which is crucial for cellular energy and longevity. By combating oxidative stress, it visibly reduces fine lines, wrinkles, and other signs of premature aging. Effective Anti-Inflammatory & Soothing AgentSkin inflammation is at the root of many concerns, from sensitivity and redness to acne. DropBright® Phlor demonstrates significant anti-inflammatory properties, helping to calm skin, reduce irritation, and alleviate conditions like atopic dermatitis. It works by inhibiting inflammatory pathways and mediators like histamine. Remarkable Penetration EnhancerUniquely, DropBright® Phlor acts as a safe and effective transdermal penetration booster. It improves the skin's absorption of other valuable actives in a formulation—such as Vitamin C, peptides, or lidocaine—ensuring they reach deeper layers where they are most effective, thereby maximizing the performance of the entire product. Hair Care Benefits: Combating Hair LossEmerging research highlights DropBright® Phlor's role in scalp health. It helps inhibit follicular cell apoptosis (programmed cell death) by modulating specific inflammatory pathways (NF-κB), potentially improving hair density and reducing hair loss. Beyond Beauty: Holistic Wellness Applications DropBright® Phlor's benefits extend far beyond topical application, showcasing significant potential in the nutraceutical and functional food space. Internal Antioxidant & Anti-Aging: Supports cellular health from within. Liver Protection: Shown to offer protective effects against chemical-induced liver damage. Anxiety Relief & Mood Support: Studies indicate an anti-anxiety effect by modulating stress responses. Functional Food & Beverage: Used in dietary supplements, solid drinks, and health beverages for immune support, metabolism promotion, and overall wellness. It also serves as a natural flavor modifier, perfect for masking bitterness in "zero-sugar" or low-sugar products. Trusted by Brands, Backed by Science DropBright® Phlor is no longer a niche ingredient. It has been adopted by leading skincare brands worldwide, most notably as a star component in SkinCeuticals' (L'Oréal) acclaimed formulations. Its presence in high-end serums and creams validates its prestige and proven results in the market. Seamless Integration into Formulations DropBright® Phlor is a highly stable, off-white to light yellow powder with a purity of ≥95%. It is recommended for use at 0.1–2.0% in cosmetic formulations. For optimal stability, store in a cool, dry place, protected from light. Sample Application: 2% DropBright® Phlor Booster SerumThis simple yet powerful formulation showcases how to incorporate DropBright® Phlor with other antioxidants like Vitamin C and Ferulic Acid for a synergistic effect. The Future is Rooted in Nature DropBright® Phlor stands as a testament to the power of botanicals harnessed through science. It offers a rare combination of proven cosmetic efficacy and internal health benefits, all within a framework of outstanding safety. For formulators and brands looking to create the next generation of multifunctional beauty and wellness products, DropBright® Phlor is an indispensable ingredient. It’s not just about treating the skin's surface; it’s about promoting holistic radiance from the inside out. Discover the power of purity. Discover DropBright® Phlor. Please contact: judyzhou@drop-bio.com