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In recent years, oligopeptide-1 has emerged as a standout ingredient in the cosmetics industry. This highly active skincare component has gained significant attention, appearing in numerous high-end formulations. But what exactly makes it so popular and effective?   What is Oligopeptide-1?   Oligopeptide-1, also called as tripeptide-1, is a small molecule composed of three amino acids, designed to mimic the body’s natural signaling peptides. Its unique structure allows it to penetrate deep into the skin and “communicate” with skin cells, activating repair and regeneration mechanisms.     The Key Benefits of Oligopeptide-1   Oligopeptide-1 has become a sought-after ingredient thanks to its wide-ranging skincare benefits:   Boosts Collagen Production As we age, collagen levels in the skin decline, leading to wrinkles and loss of elasticity. Oligopeptide-1 stimulates fibroblasts to produce collagen, helping to firm the skin and reduce fine lines.   Repairs the Skin Barrier It strengthens the skin’s natural barrier, improving resilience and protecting against environmental damage. This makes it especially beneficial for sensitive skin.   Accelerates Skin Healing Mimicking the effects of growth factors, oligopeptide-1 promotes faster cell turnover and repair, making it effective for reducing acne scars and addressing damaged skin.   Antioxidant and Anti-Inflammatory Properties Oligopeptide-1 combats free radical damage while soothing inflammation, helping maintain a calm and healthy complexion.   Why Are More People Choosing Products with Oligopeptide-1 ?   Effective Yet Gentle: Oligopeptide-1 works in harmony with the skin’s natural processes and is non-irritating, making it suitable for all skin types, including sensitive skin.   Backed by Science: Research has demonstrated that oligopeptide-1 significantly increases collagen production and improves skin quality, earning it credibility in the skincare world.     Versatile Benefits: Beyond anti-aging, it addresses multiple skin concerns, offering a comprehensive approach to skincare.     Oligopeptide-1 has become a favorite in the cosmetics industry due to its exceptional anti-aging, repair, and protective properties. It not only helps maintain youthful-looking skin but also addresses a variety of skin concerns. With its versatility and effectiveness, it’s no wonder oligopeptide-1 is celebrated as a powerhouse ingredient. Adding a product with oligopeptide-1 to your skincare routine could be your next step toward healthier, more radiant skin!   If you are interested in our products and want to know more details, please contact judyzhou@drop-bio.com.

  Small-molecule peptides have become a trending ingredient in skincare, often touted for their anti-aging benefits. But do they truly live up to the hype when it comes to reducing wrinkles? Let’s explore the science behind their effectiveness.   What Are Small-Molecule Peptides?   Small-molecule peptides are short chains of 2–10 amino acids with low molecular weight, making them easy to absorb through the skin. Once they penetrate the skin barrier, they act directly on the dermis. Common types include tetrapeptides, hexapeptides, and copper peptides, known for stimulating collagen production, enhancing skin elasticity, and providing antioxidant protection.   How Do They Work Against Wrinkles?   1.Stimulating Collagen Production Collagen loss is a key factor in wrinkle formation. Small-molecule peptides activate fibroblasts, boosting collagen synthesis to improve skin firmness and reduce fine lines and wrinkles.   2.Antioxidant Protection Free radicals can damage skin cells and accelerate aging. Small-molecule peptides have antioxidant properties that neutralize free radicals, reducing oxidative stress from UV exposure and pollution.   3.Relaxing Facial Muscles Some peptides, like hexapeptides, block nerve signals to relax facial muscles, effectively softening expression lines such as crow’s feet and forehead wrinkles.   Is There Scientific Evidence?   Studies show that consistent use of peptide-infused skincare products can visibly improve skin elasticity and smoothness within weeks. For instance, 0.1% tetrapeptide-1(0.1mg/mL DropPet® TR-1P) has a collagen-promoting effect, which has been found to significantly reduce crow’s feet and nasolabial folds. However, the effectiveness depends on factors like peptide concentration, formulation, and absorption. Poorly designed products may fail to deliver the desired results.     How to Choose Skincare with Small-Molecule Peptides?   1.Check the Ingredients: Look for clearly labeled peptides like tetrapeptides, hexapeptides, or copper peptides.   2.Prioritize Concentration: Higher peptide concentrations typically yield better results.   3.Be Consistent: Long-term use, combined with good skincare habits like sun protection and hydration, enhances effectiveness.   Conclusion   Small-molecule peptides show promising results in reducing wrinkles, particularly by stimulating collagen production and combating oxidative stress. While they’re not a “magic cure,” they are a valuable tool for slowing down the signs of aging. With the right product and consistent use, small-molecule peptides could become your go-to ally in the fight against wrinkles.     Your skin is in a race against time—small-molecule peptides might just be the secret to staying ahead!   If you are interested in our products and want to know more details, please contact judyzhou@drop-bio.com.

Surfactants, classified under the “catalysts and various auxiliaries” branch of the fine chemicals industry, are an indispensable part of modern production. Often referred to as the “MSG of the industrial world,” they find applications across virtually all fine chemical sectors, including industrial processes, agriculture, personal care, and new material development.   In recent years, personal care and cleaning products have become two of the most significant global consumer markets. Surfactants are key ingredients in these products and are among the substances that come into frequent contact with the skin. Depending on their hydrophilic-lipophilic balance (HLB) value, surfactants can serve multiple functions, such as cleaning, foaming, emulsifying, wetting, dispersing, and solubilizing.   However, many widely used surfactants, such as alkyl sulfonates and alkyl sulfates, are directly applied to the skin in rinse-off personal care products like shampoos and body washes. These compounds may cause skin irritation and allergic reactions, raising concerns about their safety.   Sophorolipids: A Safer, Eco-Friendly Alternative     Sophorolipids, a class of glycolipid biosurfactants produced by yeast fermentation, have gained attention for their unique properties. They are non-toxic, biodegradable, and environmentally friendly, making them one of the most promising natural surfactants with significant market potential.   Sophorolipids provide multiple benefits, including:   Functional Advantages: Effective at dispersing, wetting, retaining moisture, lubricating, and emulsifying. Mild surfactant properties suitable for sensitive applications. Gentle antibacterial effects, efficiently inhibiting Propionibacterium acnes and Lactobacillus. Anti-inflammatory activity, reducing the release of inflammatory cytokines. Inhibition of lipase activity, preventing the breakdown of sebum into free fatty acids.   Skin Benefits: Stimulates dermal fibroblast metabolism and promotes collagen synthesis. Neutralizes free radicals and inhibits elastase activity, enhancing skin elasticity and repair. Activates macrophages and supports fibrinolytic functions.   Environmental and Safety Features: Heat-resistant and stable across a wide pH range. Safe and non-toxic with no irritation to the skin. Fully biodegradable and environmentally sustainable.   Growing Market Adoption   Due to their exceptional performance and safety profile, sophorolipids have already been adopted by leading international brands in personal care and cosmetic products. These end-use products are now widely available in markets across the EU, the US, Japan, and China.

Adenosine is a common active ingredient in skincare products, valued for its potential anti-aging and skin-repairing properties. Here are some of the key benefits of adenosine for the skin: Adenosine boosts the energy metabolism of skin cells and stimulates collagen production, which helps to smooth fine lines and wrinkles while improving skin elasticity and firmness.It also strengthens the skin barrier, contributing to a smoother and healthier complexion. Adenosine has anti-inflammatory properties that can soothe sensitive skin and reduce redness and irritation caused by inflammation. Adenosine stimulates microcirculation in the skin, improving dullness and making skin look more radiant and healthy. Adenosine is often considered a gentle active ingredient for all skin types, including sensitive skin. Precautions： The concentration of adenosine in skincare products is generally low (0.1%-1%), which is sufficient to be effective without irritating the skin. Adenosine can work synergistically with other anti-aging ingredients (e.g., niacinamide, vitamin C), but avoid using it together with ingredients that may cause irritation (e.g., high concentrations of fruit acids).

Sensitive skin often struggles with redness, irritation, and an impaired skin barrier, making it prone to discomfort and inflammation. Vitamin B12 (cobalamin), has emerged as an ideal ingredient for soothing and restoring sensitive skin due to its unique anti-inflammatory and reparative properties. One of the highlights of Vitamin B12 is its excellent anti-inflammatory effects. Dermatitis symptom scores decreased significantly more on the side treated with VB12 cream than on the side treated with blank cream. By reducing the level of inflammation, Vitamin B12 relieves redness and irritation, providing an immediate soothing effect on damaged skin. In addition, vitamin B12 plays a key role in repairing the skin barrier. It promotes protein synthesis, particularly the production of keratin and collagen, which are essential for maintaining the skin's protective layer. A strengthened barrier not only helps lock in moisture, but also protects against external stimuli, thus making the skin less sensitive. Vitamin B12 also possesses powerful antioxidant properties that neutralize free radicals and reduce oxidative stress caused by environmental factors such as UV rays and pollution. This protective effect further reduces the feeling of skin irritation and supports skin health. There are three different specifications of DropCare® VB12 availabled to customers. Gentle and highly effective, Vitamin B12 brings significant improvement to sensitive skin through its multiple actions of soothing, repairing, and protecting, while enhancing the skin's resilience and comfort.

Mandelic acid is an alpha hydroxy acid (AHA) with a relatively large molecular structure, which means it penetrates the skin more slowly and is therefore considered gentler compared to other acids. Due to its lipophilic nature, mandelic acid is particularly suitable for oily and acne-prone skin. Its oil-regulating effects include the following: 1. Dissolving Oil in Pores: Mandelic acid can penetrate deep into the pores to help dissolve excess sebum, clearing out debris that clogs pores and reducing the formation of blackheads and acne. 2. Regulating Oil Secretion: By removing excess oil from the pores, mandelic acid gradually helps balance oil secretion, leaving the skin less shiny and with a fresher appearance. 3. Gentle Exfoliation: As a mild AHA, mandelic acid promotes the shedding of dead skin cells, making the skin smoother and more radiant. This gentle exfoliation helps prevent clogged pores caused by excess buildup.   In addition, mandelic acid has antibacterial and skin-brightening properties, making it suitable for regular use. When using mandelic acid, it’s recommended to introduce it gradually and always pair it with good sun protection to achieve optimal skincare benefits.

Retinoids are substances that are similar in structure and function to retinol, including: Drugs such as retinoic acid (RA), isotretinoin, adapalene, tazarotene, etc.; Retinol (retinol), retinaldehyde, retinyl palmitate, retinyl propionate, retinyl retinoate, and now the up-and-coming hydroxypinazone retinoate (HPR), among others. These substances can be converted into each other, so that there is a transformation pathway: After the body absorbs retinol, if it can't consume it, it converts it into retinyl palmitate and stores it, and when needed, hydrolyzes the palmitate bond with esterase (the red position in the retinol ester structure diagram on the right is broken), and retinol is released.Retinol is stripped of a hydrogen atom and oxidized to become retinaldehyde, which is an intermediate state. Retinaldehyde is further oxidized, adding an oxygen atom that becomes retinoic acid.Retinoic acid (tretinoin/retinoid) is the actual form of retinoid that enters the nucleus to bind to trans-retinoin reaction elements (RAR/RXR) and initiates the corresponding gene expression. It not only retains the efficacy group of tretinoin, but can directly bind to the receptor; It also covers the irritating groups and improves the physical and chemical stability. Cosmetics containing HPR (Hydroxypinacolone Retinoate)  can be used even on VA-sensitive skin, but note that pregnant women should not use them!        

A quick and easy way to get a healthy wheat-skin tone is to apply a tanning product. When selecting a tanning product, people tend to choose different products based on the degree of color they want to achieve. In fact, the main efficacy substance of most products is dihydroxyacetone(DHA). The dosage of dihydroxyacetone(DHA) added determines the final degree of coloration of the product on the skin. So what's the mechanism of dihydroxyacetone discoloration on the skin? Dihydroxyacetone and proteins in the skin undergo a Malanin reaction, turning the cuticle proteins brown.The specific reaction principle is as follows: Dihydroxyacetone(DHA) does not damage the skin, and is considered a safe skin coloring agent. The color is not removed by simple washing, swimming, or natural perspiration, but it only lasts for 5 to 7 days, as skin cells are continuously being shed. Exfoliation, tape stripping, prolonged water submersion, or heavy sweating can lighten the tan, as these all contribute to rapid dead skin cell pealing. Today, dihydroxyacetone(DHA) is the main active ingredient in virtually all sunless tanning skincare preparations. The above pictures were taken from some subjects in a clinical experiment of DropBio. The coloring was recorded after 3 consecutive times (once a day) of using Instant Tanning Mousse with 10% DropBio@ DHA, and the subsequent fading was continuously recorded. So Dihydroxyacetone(DHA) is a very effective ingredient for self-tanning.  

As we all know, ceramide is a lipid that is similar in structure to the substance that makes up the cuticle of the skin, so it can quickly penetrate the skin and maintain the renewal of the skin's natural protective layer, maintain the balance of natural hydration. When combined with the moisture in the cuticle, it can form a net-like structure to firmly lock the moisture. Ceramide is an important skin-activating ingredient in the cuticle that strengthens the skin barrier, rebuilds cells, and reduces the effects of the external environment by forming effective skin surface barriers.      When Ceramide is added to the damaged skin, the composition of the lipids between the cells is improved and the cells on the surface of the skin become compact and regular again.While the moisture inside the skin is locked in, the outside irritation and bacteria can no longer penetrate the skin's surface, effectively reducing sensitivity and acne formation, so Ceramide is a safe, natural and highly effective skin care ingredient.

Vitamin C (Ascorbic Acid) is a cosmetic superstar, renowned for its potent antioxidant punch, ability to brighten skin, fade hyperpigmentation, stimulate collagen, and combat signs of aging. Yet, its notoriously poor stability – vulnerable to light, heat, air, and water – has long plagued formulators, limiting its efficacy in finished products. Enter the advanced, stable derivatives: DropBrigt® SAP (Sodium Ascorbyl Phosphate) and DropBrigt® MAP (Magnesium Ascorbyl Phosphate). These innovative ingredients deliver all the coveted benefits of Vitamin C, without the instability headaches.   Why Choose Stable Vitamin C Derivatives? Traditional Ascorbic Acid breaks down rapidly, turning products brown and losing potency. DropBrigt® SAP and MAP overcome this fundamental challenge. Their phosphate ester bonds shield the active Vitamin C moiety, offering exceptional shelf-life stability within well-formulated products. Once applied to the skin, naturally occurring enzymes (phosphatases) cleave this bond, efficiently releasing pure, active Ascorbic Acid right where it's needed. Introducing DropBrigt® SAP: The Hydration-Friendly Stabilizer DropBrigt® SAP is the water-soluble champion of stable Vitamin C delivery. Superior Stability: Significantly more stable than pure Ascorbic Acid, resisting oxidation far better under typical formulation and storage conditions. Key Benefits: Potent Antioxidant: Neutralizes damaging free radicals and reactive oxygen species (ROS), protecting skin from environmental aggressors. Skin Brightening & Even Tone: Helps inhibit melanin production, reducing the appearance of dark spots and promoting a more radiant, uniform complexion. Collagen Support: Contributes to firmer, more youthful-looking skin by supporting collagen synthesis. Skin Conditioning: Helps improve overall skin texture and health. Formulation Savvy: Solubility: Highly soluble in water (up to 64%), glycerin (13.2%), and propylene glycol (1.6%). Insoluble in ethanol, IPM, triglycerides (e.g., caprylic/capric triglyceride), and C12-15 alkyl benzoate. Penetration: Primarily hydrophilic nature means penetration is lower; it acts effectively on the skin's surface and upper layers. Stability is Key: While stable, protect DropBrigt® SAP! Crucial guidelines: Temperature: Add during the cool phase (< 40°C). pH: Formulate within a pH range of 6.5 or above for optimal stability. A buffer system is highly recommended. Chelation: Incorporate a chelating agent (e.g., EDTA, Sodium Phytate) to sequester destabilizing metal ions. Storage: Finished products are most stable when stored below 25°C. Synergy: Often paired with lipid-soluble antioxidants like Vitamin E Acetate for a comprehensive antioxidant defense system. Introducing DropBrigt® MAP: The Penetration Powerhouse DropBrigt® MAP takes stable Vitamin C a step further, offering exceptional skin bioavailability. Enhanced Delivery & Longevity: Engineered for superior penetration into the epidermis, reaching vital layers like the basal layer. Skin absorption is significantly higher (reportedly ~8x more than pure Ascorbic Acid). Sustained Release: Once absorbed, it provides a reservoir effect, releasing active Vitamin C gradually over an extended period (studies suggest >12 hours in the stratum corneum). Key Benefits: All Core Vitamin C Actions: Powerful antioxidant defense, brightening, inhibition of melanogenesis, stimulation of collagen synthesis. Barrier Support: Promotes the production of collagen essential for a healthy skin barrier. Targeted Protection: Effectively combats excess ROS and oxidative stress deep within the skin. Formulation Savvy: Solubility: Highly soluble in water and dilute acids. Insoluble in ethanol, chloroform, ether, and most oils. Penetration: Excellent epidermal penetration due to its molecular structure. Stability First: Temperature: Add during the cool phase (< 45°C). pH: Formulate within a pH range of 6.0 - 7.5, with 6.5 being the sweet spot for optimal stability and efficacy. Buffering is advised. Chelation: Essential to include a chelating agent. Storage: Cool storage (<25°C) is recommended for long-term stability. Usage: Effective at concentrations of 1-3%. DropBrigt® SAP vs. MAP: Choosing Your Champion Feature DropBrigt® SAP (Sodium Ascorbyl Phosphate) DropBrigt® MAP (Magnesium Ascorbyl Phosphate) Primary Strength High Water Solubility, Surface Stability Superior Skin Penetration & Longevity Solubility High in Water, Glycerin, PG High in Water, Dilute Acid Key Benefit Surface Antioxidant, Brightening, Conditioning Deep Delivery, Prolonged Action, Collagen Boost Ideal For Toners, Gels, Light Serums, Cleansers Targeted Serums, Treatments, Anti-Aging Creams Penetration Lower (Surface/Follicular) High (Reaches Basal Layer) pH Range > 6.5 (Optimal Stability) 6.0 - 7.5 (Optimal 6.5) Add Temp < 40°C < 45°C Typical Use Broad-spectrum stabilization 1-3% Formulate with Confidence, Deliver Results DropBrigt® SAP and DropBrigt® MAP provide the solution formulators demand: clinically proven Vitamin C benefits delivered through inherently stable, effective, and versatile ingredients. By following the straightforward formulation guidelines – controlling temperature during addition, buffering to the optimal pH (6.5+ for SAP, ~6.5 for MAP), and including a chelating agent – you can create high-performance, visually stable, and efficacious products that consumers will love. Unlock the true potential of Vitamin C without compromise. Elevate your formulations with DropBrigt® SAP and DropBrigt® MAP – the stable, smart choice for radiant, youthful, and protected skin. If you are interested in our products and want to know more details, please contact judyzhou@drop-bio.com.

The PGA Revolution: One Ingredient, Two Powerful Profiles In the quest for breakthrough hydrators, Polyglutamic Acid (PGA) has emerged as a game-changer. But not all PGAs are created equal. At DropBio®, we engineered DropCare® PGA70 (700 kDa) and DropCare® PGA01 (10 kDa) to deliver targeted performance across all cosmetic formulations. Here’s why molecular weight matters: The Science Behind PGA Sodium Polyglutamate is a natural, fermentation-derived polymer with a unique γ-peptide bond structure (linking α-amino and γ-carboxyl groups). Its secret lies in: 5000%+ water-binding capacity (outperforming hyaluronic acid) Dense carboxyl side chains forming H-bond networks Biofilm-forming ability that locks moisture into skin Tailored Solutions: Molecular Weight Magic Property DropCare® PGA70 (700 kDa) DropCare® PGA01 (10 kDa) Primary Function Surface Film-Former Deep Skin Penetrator Texture Velvety-thick Featherlight Key Benefits • 24H barrier-locking hydration• Wrinkle-smoothing film• Enhances product spreadability • Boosts NMF synthesis• Transports actives deep into skin• Instant plumping effect Best For Creams/Masks/Leave-on products Serums/Toners/Rinse-off formulas Proven Efficacy: Beyond Basic Moisturization Both variants deliver multi-mechanistic anti-aging results:✅ 3X Hyaluronic Acid Boost (in-vivo data)✅ 28% Reduction in TEWL after 4 weeks✅ 19% Improvement in skin elasticity✅ Melanin Inhibition for brightening Why Formulators Choose DropCare® ▶ PGA70 (700 kDa) – The Shield Creates breathable moisture-trapping mesh Perfect for high-viscosity anti-aging creams Use at 0.5-1.0% for cushion-like texture ▶ PGA01 (10 kDa) – The Spear Penetrates stratum corneum in <30 sec Ideal for watery essences & boosters Effective at 0.1-0.5% with zero tackiness Application Genius Pair them for synergistic effects: Cleanser: PGA01 (0.2%) → Preps skin for absorption Toner: PGA01 (0.3%) + PGA70 (0.1%) → Multi-depth hydration Cream: PGA70 (0.8%) → Seals in active ingredients If you are interested in our products and want to know more details, please contact judyzhou@drop-bio.com.

In an era demanding safer, high-performance preservatives, DropPrev® MPB and its optimized variant DropPrev® MPB10 redefine cosmetic preservation through groundbreaking science. Derived from nature, perfected by innovation, these halogen-free solutions set new standards for efficacy, safety, and formulation flexibility. The Science Behind DropPrev® MPB INCI: α-Terpinene-5-ol (o-Cymen-5-ol) CAS No: 3228-02-2 | Mol. Formula: C₁₀H₁₄O Natural Origin: A stable isomer of thymol (found in thyme oil), retaining botanical benefits while outperforming its source. Why Formulators Choose MPB: "Antibacterial activity surpassing thymol by orders of magnitude" ✅ Ultra-Low Dosage: Effective at 0.01–0.1% ✅ Halogen/Heavy Metal-Free: Meets global regulatory standards (incl. Japanese Pharmacopeia) ✅ Multi-Functional: Combines preservation with UV absorption, antioxidant activity, and mild astringency DropPrev® MPB10: Microemulsion Breakthrough This pre-dispersed system (INCI: o-Cymen-5-ol, Isopentyldiol, PEG-40 Hydrogenated Castor Oil, PPG-26-Buteth-26) solves MPB’s solubility challenges while amplifying benefits: Key Innovations:🔬 Microemulsion Technology: Prevents crystallization in aqueous systems Enables crystal-clear serums, toners, and oral care products 💧 Unmatched Compatibility: Zero known ingredient conflicts pH-stable (3–8), resisting salt-induced passivation Clinical Advantages: Broad-Spectrum Efficacy: Eliminates bacteria, fungi, yeast, and dental plaque pathogens at ≤0.5% dosage Skin Health Benefits: Reduces oiliness, combats acne/comedones Sensory Excellence: Near-zero odor, taste, and irritation (non-sensitizing at 2%) Why This Changes Formulation Traditional Preservatives DropPrev® MPB10 Limited pH stability Stable in acidic/alkaline environments Corrosive to packaging Non-corrosive (metal/rubber/plastic safe) Halogen-containing Eco-compliant & biodegradable Functional trade-offs Multifunctional: Preservative + Antioxidant + Skin Actives Applications Revolutionized: Skin Care: Acne serums, moisturizers (0.3–0.8%) Oral Hygiene: Mouthwashes, gels (0.2–0.5%) Transparent Formulations: Essences, toners (0.5–1.0%) Sustainability Meets Performance DropPrev® aligns with clean beauty demands: Plant-Derived Carbon: Renewable sourcing from botanical precursors Low Ecotoxicity: Biodegradable without bioaccumulation risks Energy-Efficient: Cold-process compatible (add at RT) "The first preservative that actively contributes to skin health while defeating microbes at ultralow concentrations." Technical Support Available: Request formulation guides for: Water-phase incorporation protocols Emulsion stabilization techniques pH adjustment thresholds Packaging Options: DropPrev® MPB: 1kg bags, 25kg barrels DropPrev® MPB10: 1kg bottles, 5kg/25kg barrels Reimagine preservation: Where uncompromised safety, efficacy, and elegance converge. If you are interested in our products and want to know more details, please contact judyzhou@drop-bio.com.