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In recent years, oligopeptide-1 has emerged as a standout ingredient in the cosmetics industry. This highly active skincare component has gained significant attention, appearing in numerous high-end formulations. But what exactly makes it so popular and effective?   What is Oligopeptide-1?   Oligopeptide-1, also called as tripeptide-1, is a small molecule composed of three amino acids, designed to mimic the body’s natural signaling peptides. Its unique structure allows it to penetrate deep into the skin and “communicate” with skin cells, activating repair and regeneration mechanisms.     The Key Benefits of Oligopeptide-1   Oligopeptide-1 has become a sought-after ingredient thanks to its wide-ranging skincare benefits:   Boosts Collagen Production As we age, collagen levels in the skin decline, leading to wrinkles and loss of elasticity. Oligopeptide-1 stimulates fibroblasts to produce collagen, helping to firm the skin and reduce fine lines.   Repairs the Skin Barrier It strengthens the skin’s natural barrier, improving resilience and protecting against environmental damage. This makes it especially beneficial for sensitive skin.   Accelerates Skin Healing Mimicking the effects of growth factors, oligopeptide-1 promotes faster cell turnover and repair, making it effective for reducing acne scars and addressing damaged skin.   Antioxidant and Anti-Inflammatory Properties Oligopeptide-1 combats free radical damage while soothing inflammation, helping maintain a calm and healthy complexion.   Why Are More People Choosing Products with Oligopeptide-1 ?   Effective Yet Gentle: Oligopeptide-1 works in harmony with the skin’s natural processes and is non-irritating, making it suitable for all skin types, including sensitive skin.   Backed by Science: Research has demonstrated that oligopeptide-1 significantly increases collagen production and improves skin quality, earning it credibility in the skincare world.     Versatile Benefits: Beyond anti-aging, it addresses multiple skin concerns, offering a comprehensive approach to skincare.     Oligopeptide-1 has become a favorite in the cosmetics industry due to its exceptional anti-aging, repair, and protective properties. It not only helps maintain youthful-looking skin but also addresses a variety of skin concerns. With its versatility and effectiveness, it’s no wonder oligopeptide-1 is celebrated as a powerhouse ingredient. Adding a product with oligopeptide-1 to your skincare routine could be your next step toward healthier, more radiant skin!   If you are interested in our products and want to know more details, please contact judyzhou@drop-bio.com.

  Small-molecule peptides have become a trending ingredient in skincare, often touted for their anti-aging benefits. But do they truly live up to the hype when it comes to reducing wrinkles? Let’s explore the science behind their effectiveness.   What Are Small-Molecule Peptides?   Small-molecule peptides are short chains of 2–10 amino acids with low molecular weight, making them easy to absorb through the skin. Once they penetrate the skin barrier, they act directly on the dermis. Common types include tetrapeptides, hexapeptides, and copper peptides, known for stimulating collagen production, enhancing skin elasticity, and providing antioxidant protection.   How Do They Work Against Wrinkles?   1.Stimulating Collagen Production Collagen loss is a key factor in wrinkle formation. Small-molecule peptides activate fibroblasts, boosting collagen synthesis to improve skin firmness and reduce fine lines and wrinkles.   2.Antioxidant Protection Free radicals can damage skin cells and accelerate aging. Small-molecule peptides have antioxidant properties that neutralize free radicals, reducing oxidative stress from UV exposure and pollution.   3.Relaxing Facial Muscles Some peptides, like hexapeptides, block nerve signals to relax facial muscles, effectively softening expression lines such as crow’s feet and forehead wrinkles.   Is There Scientific Evidence?   Studies show that consistent use of peptide-infused skincare products can visibly improve skin elasticity and smoothness within weeks. For instance, 0.1% tetrapeptide-1(0.1mg/mL DropPet® TR-1P) has a collagen-promoting effect, which has been found to significantly reduce crow’s feet and nasolabial folds. However, the effectiveness depends on factors like peptide concentration, formulation, and absorption. Poorly designed products may fail to deliver the desired results.     How to Choose Skincare with Small-Molecule Peptides?   1.Check the Ingredients: Look for clearly labeled peptides like tetrapeptides, hexapeptides, or copper peptides.   2.Prioritize Concentration: Higher peptide concentrations typically yield better results.   3.Be Consistent: Long-term use, combined with good skincare habits like sun protection and hydration, enhances effectiveness.   Conclusion   Small-molecule peptides show promising results in reducing wrinkles, particularly by stimulating collagen production and combating oxidative stress. While they’re not a “magic cure,” they are a valuable tool for slowing down the signs of aging. With the right product and consistent use, small-molecule peptides could become your go-to ally in the fight against wrinkles.     Your skin is in a race against time—small-molecule peptides might just be the secret to staying ahead!   If you are interested in our products and want to know more details, please contact judyzhou@drop-bio.com.

Surfactants, classified under the “catalysts and various auxiliaries” branch of the fine chemicals industry, are an indispensable part of modern production. Often referred to as the “MSG of the industrial world,” they find applications across virtually all fine chemical sectors, including industrial processes, agriculture, personal care, and new material development.   In recent years, personal care and cleaning products have become two of the most significant global consumer markets. Surfactants are key ingredients in these products and are among the substances that come into frequent contact with the skin. Depending on their hydrophilic-lipophilic balance (HLB) value, surfactants can serve multiple functions, such as cleaning, foaming, emulsifying, wetting, dispersing, and solubilizing.   However, many widely used surfactants, such as alkyl sulfonates and alkyl sulfates, are directly applied to the skin in rinse-off personal care products like shampoos and body washes. These compounds may cause skin irritation and allergic reactions, raising concerns about their safety.   Sophorolipids: A Safer, Eco-Friendly Alternative     Sophorolipids, a class of glycolipid biosurfactants produced by yeast fermentation, have gained attention for their unique properties. They are non-toxic, biodegradable, and environmentally friendly, making them one of the most promising natural surfactants with significant market potential.   Sophorolipids provide multiple benefits, including:   Functional Advantages: Effective at dispersing, wetting, retaining moisture, lubricating, and emulsifying. Mild surfactant properties suitable for sensitive applications. Gentle antibacterial effects, efficiently inhibiting Propionibacterium acnes and Lactobacillus. Anti-inflammatory activity, reducing the release of inflammatory cytokines. Inhibition of lipase activity, preventing the breakdown of sebum into free fatty acids.   Skin Benefits: Stimulates dermal fibroblast metabolism and promotes collagen synthesis. Neutralizes free radicals and inhibits elastase activity, enhancing skin elasticity and repair. Activates macrophages and supports fibrinolytic functions.   Environmental and Safety Features: Heat-resistant and stable across a wide pH range. Safe and non-toxic with no irritation to the skin. Fully biodegradable and environmentally sustainable.   Growing Market Adoption   Due to their exceptional performance and safety profile, sophorolipids have already been adopted by leading international brands in personal care and cosmetic products. These end-use products are now widely available in markets across the EU, the US, Japan, and China.

Adenosine is a common active ingredient in skincare products, valued for its potential anti-aging and skin-repairing properties. Here are some of the key benefits of adenosine for the skin: Adenosine boosts the energy metabolism of skin cells and stimulates collagen production, which helps to smooth fine lines and wrinkles while improving skin elasticity and firmness.It also strengthens the skin barrier, contributing to a smoother and healthier complexion. Adenosine has anti-inflammatory properties that can soothe sensitive skin and reduce redness and irritation caused by inflammation. Adenosine stimulates microcirculation in the skin, improving dullness and making skin look more radiant and healthy. Adenosine is often considered a gentle active ingredient for all skin types, including sensitive skin. Precautions： The concentration of adenosine in skincare products is generally low (0.1%-1%), which is sufficient to be effective without irritating the skin. Adenosine can work synergistically with other anti-aging ingredients (e.g., niacinamide, vitamin C), but avoid using it together with ingredients that may cause irritation (e.g., high concentrations of fruit acids).

Sensitive skin often struggles with redness, irritation, and an impaired skin barrier, making it prone to discomfort and inflammation. Vitamin B12 (cobalamin), has emerged as an ideal ingredient for soothing and restoring sensitive skin due to its unique anti-inflammatory and reparative properties. One of the highlights of Vitamin B12 is its excellent anti-inflammatory effects. Dermatitis symptom scores decreased significantly more on the side treated with VB12 cream than on the side treated with blank cream. By reducing the level of inflammation, Vitamin B12 relieves redness and irritation, providing an immediate soothing effect on damaged skin. In addition, vitamin B12 plays a key role in repairing the skin barrier. It promotes protein synthesis, particularly the production of keratin and collagen, which are essential for maintaining the skin's protective layer. A strengthened barrier not only helps lock in moisture, but also protects against external stimuli, thus making the skin less sensitive. Vitamin B12 also possesses powerful antioxidant properties that neutralize free radicals and reduce oxidative stress caused by environmental factors such as UV rays and pollution. This protective effect further reduces the feeling of skin irritation and supports skin health. There are three different specifications of DropCare® VB12 availabled to customers. Gentle and highly effective, Vitamin B12 brings significant improvement to sensitive skin through its multiple actions of soothing, repairing, and protecting, while enhancing the skin's resilience and comfort.

Mandelic acid is an alpha hydroxy acid (AHA) with a relatively large molecular structure, which means it penetrates the skin more slowly and is therefore considered gentler compared to other acids. Due to its lipophilic nature, mandelic acid is particularly suitable for oily and acne-prone skin. Its oil-regulating effects include the following: 1. Dissolving Oil in Pores: Mandelic acid can penetrate deep into the pores to help dissolve excess sebum, clearing out debris that clogs pores and reducing the formation of blackheads and acne. 2. Regulating Oil Secretion: By removing excess oil from the pores, mandelic acid gradually helps balance oil secretion, leaving the skin less shiny and with a fresher appearance. 3. Gentle Exfoliation: As a mild AHA, mandelic acid promotes the shedding of dead skin cells, making the skin smoother and more radiant. This gentle exfoliation helps prevent clogged pores caused by excess buildup.   In addition, mandelic acid has antibacterial and skin-brightening properties, making it suitable for regular use. When using mandelic acid, it’s recommended to introduce it gradually and always pair it with good sun protection to achieve optimal skincare benefits.

Retinoids are substances that are similar in structure and function to retinol, including: Drugs such as retinoic acid (RA), isotretinoin, adapalene, tazarotene, etc.; Retinol (retinol), retinaldehyde, retinyl palmitate, retinyl propionate, retinyl retinoate, and now the up-and-coming hydroxypinazone retinoate (HPR), among others. These substances can be converted into each other, so that there is a transformation pathway: After the body absorbs retinol, if it can't consume it, it converts it into retinyl palmitate and stores it, and when needed, hydrolyzes the palmitate bond with esterase (the red position in the retinol ester structure diagram on the right is broken), and retinol is released.Retinol is stripped of a hydrogen atom and oxidized to become retinaldehyde, which is an intermediate state. Retinaldehyde is further oxidized, adding an oxygen atom that becomes retinoic acid.Retinoic acid (tretinoin/retinoid) is the actual form of retinoid that enters the nucleus to bind to trans-retinoin reaction elements (RAR/RXR) and initiates the corresponding gene expression. It not only retains the efficacy group of tretinoin, but can directly bind to the receptor; It also covers the irritating groups and improves the physical and chemical stability. Cosmetics containing HPR (Hydroxypinacolone Retinoate)  can be used even on VA-sensitive skin, but note that pregnant women should not use them!        

A quick and easy way to get a healthy wheat-skin tone is to apply a tanning product. When selecting a tanning product, people tend to choose different products based on the degree of color they want to achieve. In fact, the main efficacy substance of most products is dihydroxyacetone(DHA). The dosage of dihydroxyacetone(DHA) added determines the final degree of coloration of the product on the skin. So what's the mechanism of dihydroxyacetone discoloration on the skin? Dihydroxyacetone and proteins in the skin undergo a Malanin reaction, turning the cuticle proteins brown.The specific reaction principle is as follows: Dihydroxyacetone(DHA) does not damage the skin, and is considered a safe skin coloring agent. The color is not removed by simple washing, swimming, or natural perspiration, but it only lasts for 5 to 7 days, as skin cells are continuously being shed. Exfoliation, tape stripping, prolonged water submersion, or heavy sweating can lighten the tan, as these all contribute to rapid dead skin cell pealing. Today, dihydroxyacetone(DHA) is the main active ingredient in virtually all sunless tanning skincare preparations. The above pictures were taken from some subjects in a clinical experiment of DropBio. The coloring was recorded after 3 consecutive times (once a day) of using Instant Tanning Mousse with 10% DropBio@ DHA, and the subsequent fading was continuously recorded. So Dihydroxyacetone(DHA) is a very effective ingredient for self-tanning.  

As we all know, ceramide is a lipid that is similar in structure to the substance that makes up the cuticle of the skin, so it can quickly penetrate the skin and maintain the renewal of the skin's natural protective layer, maintain the balance of natural hydration. When combined with the moisture in the cuticle, it can form a net-like structure to firmly lock the moisture. Ceramide is an important skin-activating ingredient in the cuticle that strengthens the skin barrier, rebuilds cells, and reduces the effects of the external environment by forming effective skin surface barriers.      When Ceramide is added to the damaged skin, the composition of the lipids between the cells is improved and the cells on the surface of the skin become compact and regular again.While the moisture inside the skin is locked in, the outside irritation and bacteria can no longer penetrate the skin's surface, effectively reducing sensitivity and acne formation, so Ceramide is a safe, natural and highly effective skin care ingredient.

In the evolving world of cosmetic ingredients, Azelaic Acid has emerged as a powerhouse component, celebrated for its multi-functional benefits. DropBio® introduces two exceptional forms of this star ingredient: DropCare® AZE 60 and DropCare® AZE, both designed to meet the diverse needs of modern skincare formulations. What is Azelaic Acid? Azelaic Acid, also known as “王二酸” (Wang Er Suan) in Chinese, is a naturally occurring acid with a long-standing reputation in dermatology. Despite its common nickname “杜鹃花酸” (Du Juan Hua Suan), it is not derived from rhododendrons. Instead, the name originates from the Latin terms Azelaic acidum and Azalea. Initially discovered in the culture medium of Malassezia furfur, where oleic acid was oxidized into Azelaic Acid, this ingredient has since been recognized for its exceptional skin-brightening and acne-fighting properties. Approved for medical use in China since 2003, Azelaic Acid is now a trusted cosmetic active for its efficacy and tolerability. Introducing DropCare® AZE 60: The Next-Generation Azelaic Acid DropCare® AZE 60 is a technologically advanced form of Azelaic Acid, thoughtfully encapsulated with Hydroxypropyl Cyclodextrin and Methyl Cyclodextrin. This innovative approach overcomes traditional challenges associated with Azelaic Acid—such as poor water solubility and a gritty texture—making it ideal for stable, water-based formulations. Key Benefits of DropCare® AZE 60: Powerful Acne Treatment & Anti-Inflammatory Action:Azelaic Acid effectively inhibits Propionibacterium acnes and reduces inflammation, making it a first-line choice for mild to moderate acne. It is also highly suitable for individuals with rosacea, significantly improving facial redness and papules. Exceptional Brightening & Spot-Fading:As a potent tyrosinase inhibitor, Azelaic Acid targets melanin synthesis at its source. Clinically proven to treat hyperpigmentation, it effectively fades post-acne marks, dark spots, and enhances overall skin radiance. Gentle Yet Effective:Unlike some harsh actives, Azelaic Acid delivers remarkable results with minimal side effects. Its encapsulated form in DropCare® AZE 60 ensures a lighter texture, reduced irritation, and an optimal balance between potency and gentleness. DropCare® AZE: Pure and Potent For formulations requiring pure Azelaic Acid, DropCare® AZE offers a high-quality option with the following specifications: INCI Name: Azelaic Acid CAS No.: 123-99-9 Recommended Dosage: 1-5% (Daily Use) 5-10% (Potent Treatment) 15-20% (Specialized Care) Laboratory and clinical studies confirm that Azelaic Acid at 15-20% concentrations is highly effective against mild acne, with excellent patient tolerance for long-term use. Why Formulate with DropCare® AZE 60 and DropCare® AZE? Multi-Functional Efficacy: Address acne, inflammation, and hyperpigmentation with a single ingredient. Superior Solubility & Stability: DropCare® AZE 60’s cyclodextrin encapsulation ensures smooth integration into aqueous systems. Proven Safety: Gentle enough for daily use, yet powerful enough for clinical-level treatments. Storage & Packaging Storage: Keep at room temperature, away from moisture and light. Shelf Life: 2 years for DropCare® AZE 60 | 3 years for DropCare® AZE Packaging: Available in 1kg, 25kg, or customized packaging to suit your production needs. Formulate with Confidence. Empower Skincare. Choose DropCare® AZE 60 and DropCare® AZE from Drop(Nanjing) Bio-Tech Co., Ltd., and bring the future of high-performance, skin-friendly cosmetics to life. If you are interested in our products and want to know more details, please contact judyzhou@drop-bio.com.

In the quest for healthy, balanced skin, hydration and oil control are two sides of the same coin. For formulators and skincare enthusiasts alike, the Pyrrolidone Carboxylic Acid (PCA) salts are superstar ingredients that address these fundamental needs. Today, we're comparing two powerful members of this family: DropCare® PCA Zn and DropCare® PCA Na. While they share a common core, their unique properties make them suited for different skin concerns. Let's explore what sets them apart. The Common Hero: What is PCA? First, it’s essential to understand PCA. Pyrrolidone Carboxylic Acid is a key component of the skin’s Natural Moisturizing Factor (NMF). It’s a humectant, meaning it draws moisture from the air into the skin, helping to maintain hydration, suppleness, and a strong skin barrier. Both PCA Zn and PCA Na are water-soluble salts that deliver the superb moisturizing benefits of PCA, enhanced by their respective minerals. DropCare® PCA Zn: The Oil-Control Specialist INCI: Zinc PCA As detailed in its technical specifications, DropCare® PCA Zn is a multifunctional active that combines the moisturizing power of PCA with the therapeutic benefits of Zinc. Key Properties & Benefits: Oil Control & Anti-Acne: This is its standout feature. Zinc PCA is known to inhibit the activity of 5-alpha reductase, an enzyme that stimulates sebum production. By regulating this process, it effectively reduces shine and oiliness. Antibacterial Action: Zinc possesses inherent antibacterial properties, making it excellent for helping to calm and prevent acne breakouts. Powerful Moisturizing: It still delivers the core humectant benefits of PCA, ensuring the skin is hydrated without being greasy. This helps to relieve dryness and strengthen the barrier, even for sensitive skin. Antioxidant: It offers protective benefits against environmental stressors. Ideal For: Oily and acne-prone skin types. Serums, toners, and moisturizers targeted at shine control. Products designed for men's skincare, which is often oilier. Strengthening the skin barrier while managing sebum. Specification Snapshot: Appearance: White to Pale yellow crystalline powder pH (10% solution): 5.0-6.5 (Skin-friendly) Dosage: 0.1 - 3% DropCare® PCA Na: The Hydration Powerhouse INCI: Sodium PCA DropCare® PCA Na is the sodium salt of PCA. While we don't have its specific spec sheet here, it is widely recognized in the industry as one of the most potent humectants available—even more effective than glycerin or propylene glycol in some studies. Key Properties & Benefits: Superior Humectant: This is its primary strength. Sodium PCA has an exceptional ability to bind and retain water in the stratum corneum (the skin's outermost layer), providing intense and long-lasting hydration. Skin Barrier Support: By significantly boosting the skin's moisture levels, it helps maintain a healthy, resilient barrier, which is crucial for protecting against irritants and preventing trans-epidermal water loss (TEWL). Skin Softening & Smoothing: Excellent hydration leads to softer, smoother, and more plump skin. Compatibility: It is non-irritating and suitable for all skin types, including sensitive skin. Ideal For: Dry, dehydrated, and mature skin. Boosting the moisturizing power of any formulation—from creams and lotions to cleansers and sheet masks. Restoring hydration and comfort to sensitized or compromised skin. Head-to-Head: PCA Zn vs. PCA Na     Feature DropCare® PCA Zn DropCare® PCA Na Primary Function Oil Control, Anti-Acne Intense Moisturization Key Mineral Zinc Sodium Main Benefit Regulates sebum, antibacterial Powerful humectant, barrier support Best For Oily, Combination, Acne-Prone Skin Dry, Dehydrated, Mature, Sensitive Skin Texture Crystalline Powder Typically a Hygroscopic Liquid or Powder Can They Work Together? Absolutely! In fact, combining them can be a masterstroke for balancing combination skin. A formulation could use: PCA Na to deliver deep hydration to dry cheeks and areas. PCA Zn to control shine and breakouts in the T-zone. This synergistic approach helps achieve the ultimate goal: skin that is both sufficiently hydrated and matte. The Formulator's Takeaway The choice between DropCare® PCA Zn and PCA Na isn't about which is better, but about which is right for your product's goal. Formulating for oil control and clarity? Choose DropCare® PCA Zn. Formulating for maximum hydration and barrier health? Choose DropCare® PCA Na. Both ingredients are water-soluble, effective at low doses, and offer the proven, skin-friendly benefits of the Natural Moisturizing Factor. By understanding their distinct strengths, you can create more targeted and effective skincare solutions for every skin type. Ready to formulate? Explore the technical specifications and discover how these powerful PCA salts can elevate your next product. If you are interested in our products and want to know more details, please contact judyzhou@drop-bio.com.

In the quest for effective skincare, the focus is increasingly shifting to ingredients that don't just sit on the surface but work in harmony with the skin's natural biology. At the forefront of this movement are ceramides – the essential lipids that form the very foundation of a healthy, resilient skin barrier. Today, we're excited to introduce a groundbreaking ingredient designed to revolutionize your formulations: DropCare® Bionic 150. Why Ceramides are Non-Negotiable for Skin Health Think of your skin's barrier as a brick wall, where skin cells are the bricks and lipids (like ceramides) are the mortar. Ceramides are a crucial component of this "mortar," responsible for: Binding skin cells together to create a tight, protective shield. Sealing in moisture and vital nutrients. Protecting against environmental aggressors, bacteria, and pollutants. However, as we age, our natural ceramide levels deplete significantly. By the age of 50, our skin contains only about half the ceramides it had at 20. This decline leads to dryness, sensitivity, dullness, and visible signs of aging. To combat this, actively replenishing ceramides is not a luxury—it's a necessity. Introducing DropCare® Bionic 150: The All-in-One Ceramide Solution DropCare® Bionic 150 is not just a single ceramide; it's a sophisticated ceramide complex solution. It is expertly blended with Ceramide NP, Ceramide AP, Ceramide EOP, Phytosphingosine, and Phytosterols to mimic the skin's natural lipid composition, providing comprehensive barrier repair and moisturization. Key Functions: Intense Moisturization: Acts as a natural moisturizing factor, preventing transepidermal water loss. Barrier Repair: Reinforces the skin's stratum corneum, helping to restore its protective function. Relief: Soothes and calms the skin, making it ideal for sensitive or compromised skin types. Why Formulators Choose DropCare® Bionic 150 This innovative ingredient is engineered for both performance and ease of use: ✔ Synergistic Efficacy: The combination of multiple ceramide types, enhanced with advanced microemulsification technology, creates a powerful synergistic effect for superior skin barrier recovery. ✔ Excellent Solubility & Formulation Flexibility: We've solved the common challenge of incorporating ceramides into formulas. DropCare® Bionic 150 is readily soluble in water and easy to use in a wide range of emulsions, simplifying your production process. ✔ Convenient Liquid Form: Supplied as an off-white viscous liquid, it is easy to handle and integrate into your existing production lines. Please Note: The product is ionic, and the use of a carbomer system is not recommended. Technical Specifications at a Glance     Property Specification Appearance Off-white viscous liquid pH (1:10) 5.0 - 7.0 CERAMIDE AP, % ≥ 0.5 CERAMIDE NP, % ≥ 1.0 PHYTOSPHINGOSINE, % ≥ 0.5 Heavy metals (Pb), ppm ≤ 20.0 Arsenic (As), ppm ≤ 2.0 Total aerobic bacteria ≤ 1000 cfu/g Yeasts and molds ≤ 100 cfu/g Application & Usage Recommended For: Perfect for a wide array of high-performance skincare products, including: Serums & Essences Moisturizing Creams & Lotions Barrier Repair Treatments Anti-aging Formulations Dosage: We recommend a usage level of 0.01% - 5% to effectively boost the ceramide content in your final product. Storage: Keep sealed at room temperature, away from moisture and light. Shelf life is 2 years. Elevate your formulations with the science of barrier repair. Integrate DropCare® Bionic 150 into your next skincare innovation and deliver the profound hydration and resilience that today's consumers demand. Ready to formulate the future? Contact us today! If you are interested in our products and want to know more details, please contact judyzhou@drop-bio.com.