Anti-aging

The PGA Revolution: One Ingredient, Two Powerful Profiles In the quest for breakthrough hydrators, Polyglutamic Acid (PGA) has emerged as a game-changer. But not all PGAs are created equal. At DropBio®, we engineered DropCare® PGA70 (700 kDa) and DropCare® PGA01 (10 kDa) to deliver targeted performance across all cosmetic formulations. Here’s why molecular weight matters: The Science Behind PGA Sodium Polyglutamate is a natural, fermentation-derived polymer with a unique γ-peptide bond structure (linking α-amino and γ-carboxyl groups). Its secret lies in: 5000%+ water-binding capacity (outperforming hyaluronic acid) Dense carboxyl side chains forming H-bond networks Biofilm-forming ability that locks moisture into skin Tailored Solutions: Molecular Weight Magic Property DropCare® PGA70 (700 kDa) DropCare® PGA01 (10 kDa) Primary Function Surface Film-Former Deep Skin Penetrator Texture Velvety-thick Featherlight Key Benefits • 24H barrier-locking hydration• Wrinkle-smoothing film• Enhances product spreadability • Boosts NMF synthesis• Transports actives deep into skin• Instant plumping effect Best For Creams/Masks/Leave-on products Serums/Toners/Rinse-off formulas Proven Efficacy: Beyond Basic Moisturization Both variants deliver multi-mechanistic anti-aging results:✅ 3X Hyaluronic Acid Boost (in-vivo data)✅ 28% Reduction in TEWL after 4 weeks✅ 19% Improvement in skin elasticity✅ Melanin Inhibition for brightening Why Formulators Choose DropCare® ▶ PGA70 (700 kDa) – The Shield Creates breathable moisture-trapping mesh Perfect for high-viscosity anti-aging creams Use at 0.5-1.0% for cushion-like texture ▶ PGA01 (10 kDa) – The Spear Penetrates stratum corneum in <30 sec Ideal for watery essences & boosters Effective at 0.1-0.5% with zero tackiness Application Genius Pair them for synergistic effects: Cleanser: PGA01 (0.2%) → Preps skin for absorption Toner: PGA01 (0.3%) + PGA70 (0.1%) → Multi-depth hydration Cream: PGA70 (0.8%) → Seals in active ingredients If you are interested in our products and want to know more details, please contact judyzhou@drop-bio.com.

Vitamin C (Ascorbic Acid) is a cosmetic superstar, renowned for its potent antioxidant punch, ability to brighten skin, fade hyperpigmentation, stimulate collagen, and combat signs of aging. Yet, its notoriously poor stability – vulnerable to light, heat, air, and water – has long plagued formulators, limiting its efficacy in finished products. Enter the advanced, stable derivatives: DropBrigt® SAP (Sodium Ascorbyl Phosphate) and DropBrigt® MAP (Magnesium Ascorbyl Phosphate). These innovative ingredients deliver all the coveted benefits of Vitamin C, without the instability headaches.   Why Choose Stable Vitamin C Derivatives? Traditional Ascorbic Acid breaks down rapidly, turning products brown and losing potency. DropBrigt® SAP and MAP overcome this fundamental challenge. Their phosphate ester bonds shield the active Vitamin C moiety, offering exceptional shelf-life stability within well-formulated products. Once applied to the skin, naturally occurring enzymes (phosphatases) cleave this bond, efficiently releasing pure, active Ascorbic Acid right where it's needed. Introducing DropBrigt® SAP: The Hydration-Friendly Stabilizer DropBrigt® SAP is the water-soluble champion of stable Vitamin C delivery. Superior Stability: Significantly more stable than pure Ascorbic Acid, resisting oxidation far better under typical formulation and storage conditions. Key Benefits: Potent Antioxidant: Neutralizes damaging free radicals and reactive oxygen species (ROS), protecting skin from environmental aggressors. Skin Brightening & Even Tone: Helps inhibit melanin production, reducing the appearance of dark spots and promoting a more radiant, uniform complexion. Collagen Support: Contributes to firmer, more youthful-looking skin by supporting collagen synthesis. Skin Conditioning: Helps improve overall skin texture and health. Formulation Savvy: Solubility: Highly soluble in water (up to 64%), glycerin (13.2%), and propylene glycol (1.6%). Insoluble in ethanol, IPM, triglycerides (e.g., caprylic/capric triglyceride), and C12-15 alkyl benzoate. Penetration: Primarily hydrophilic nature means penetration is lower; it acts effectively on the skin's surface and upper layers. Stability is Key: While stable, protect DropBrigt® SAP! Crucial guidelines: Temperature: Add during the cool phase (< 40°C). pH: Formulate within a pH range of 6.5 or above for optimal stability. A buffer system is highly recommended. Chelation: Incorporate a chelating agent (e.g., EDTA, Sodium Phytate) to sequester destabilizing metal ions. Storage: Finished products are most stable when stored below 25°C. Synergy: Often paired with lipid-soluble antioxidants like Vitamin E Acetate for a comprehensive antioxidant defense system. Introducing DropBrigt® MAP: The Penetration Powerhouse DropBrigt® MAP takes stable Vitamin C a step further, offering exceptional skin bioavailability. Enhanced Delivery & Longevity: Engineered for superior penetration into the epidermis, reaching vital layers like the basal layer. Skin absorption is significantly higher (reportedly ~8x more than pure Ascorbic Acid). Sustained Release: Once absorbed, it provides a reservoir effect, releasing active Vitamin C gradually over an extended period (studies suggest >12 hours in the stratum corneum). Key Benefits: All Core Vitamin C Actions: Powerful antioxidant defense, brightening, inhibition of melanogenesis, stimulation of collagen synthesis. Barrier Support: Promotes the production of collagen essential for a healthy skin barrier. Targeted Protection: Effectively combats excess ROS and oxidative stress deep within the skin. Formulation Savvy: Solubility: Highly soluble in water and dilute acids. Insoluble in ethanol, chloroform, ether, and most oils. Penetration: Excellent epidermal penetration due to its molecular structure. Stability First: Temperature: Add during the cool phase (< 45°C). pH: Formulate within a pH range of 6.0 - 7.5, with 6.5 being the sweet spot for optimal stability and efficacy. Buffering is advised. Chelation: Essential to include a chelating agent. Storage: Cool storage (<25°C) is recommended for long-term stability. Usage: Effective at concentrations of 1-3%. DropBrigt® SAP vs. MAP: Choosing Your Champion Feature DropBrigt® SAP (Sodium Ascorbyl Phosphate) DropBrigt® MAP (Magnesium Ascorbyl Phosphate) Primary Strength High Water Solubility, Surface Stability Superior Skin Penetration & Longevity Solubility High in Water, Glycerin, PG High in Water, Dilute Acid Key Benefit Surface Antioxidant, Brightening, Conditioning Deep Delivery, Prolonged Action, Collagen Boost Ideal For Toners, Gels, Light Serums, Cleansers Targeted Serums, Treatments, Anti-Aging Creams Penetration Lower (Surface/Follicular) High (Reaches Basal Layer) pH Range > 6.5 (Optimal Stability) 6.0 - 7.5 (Optimal 6.5) Add Temp < 40°C < 45°C Typical Use Broad-spectrum stabilization 1-3% Formulate with Confidence, Deliver Results DropBrigt® SAP and DropBrigt® MAP provide the solution formulators demand: clinically proven Vitamin C benefits delivered through inherently stable, effective, and versatile ingredients. By following the straightforward formulation guidelines – controlling temperature during addition, buffering to the optimal pH (6.5+ for SAP, ~6.5 for MAP), and including a chelating agent – you can create high-performance, visually stable, and efficacious products that consumers will love. Unlock the true potential of Vitamin C without compromise. Elevate your formulations with DropBrigt® SAP and DropBrigt® MAP – the stable, smart choice for radiant, youthful, and protected skin. If you are interested in our products and want to know more details, please contact judyzhou@drop-bio.com.