Hydroxyethylpiperazine Ethane Sulfonic Acid

Unlock the hidden potential of formulations with DropBrigt® HEPES (INCI: Hydroxyethylpiperazine Ethane Sulfonic Acid, CAS 7365-45-9)—a bio-compatible buffer that transcends pH control to deliver exfoliation, brightening, and UV-protective synergy. Backed by cutting-edge 3D skin models, here’s why this versatile active belongs in your next brightening or anti-aging formula. 🌟 Triple-Action Benefits Gentle Exfoliation Weak acid (pH 4.5–6.5) with macromolecular AHA-like properties. Softens keratinocytes, smooths texture, and boosts cell turnover without irritation at recommended doses (0.5–5%). Clinical Brightening Power Proven Synergy: In 3D melanin skin models, formulations with HEPES + tranexamic acid + AA2G + niacinamide (Composition A): ↑ L* value (brightness) by 15% vs. controls (P<0.01) ↓ Melanin content by 30% (P<0.01) Outperformed fewer-actives combos (B/C) in reducing UV-induced pigmentation. UV Absorption & Penetration Boost Absorbs UVA/visible light, offering secondary photoprotection. Enhances delivery of co-actives (e.g., vitamin C, niacinamide). 🔬 Science Spotlight: Brightening Synergy Test Parameter Composition A Composition B Composition C Tranexamic Acid 3% – – AA2G 1% 1% – Niacinamide 2% 5% 6% HEPES 0.5% 0.5% 0.5% Result vs. UV-Damaged Skin ↑ L* value 15%↓ Melanin 30% Moderate improvement Minimal impact Key Insight: HEPES amplifies brightening efficacy in multi-active systems—0.5% HEPES doubled melanin reduction vs. niacinamide-only formulas. ⚙️ Formulator-Friendly Profile Solubility: Water-soluble (1M solution: clear, colorless). Stability: Heat/light-stable; pH 4–8 compatible. Addition: Flexible—cold or hot process (≤80°C). Safety: Mild irritation (IS=4.77 at 2% in chicken embryo test). Optimal use: 0.5–2% in leave-on products. ✅ Premium Quality Standards Parameter Specification Appearance White crystalline powder Purity (Assay) ≥99.5% Heavy Metals ≤10 ppm (Pb ≤2 ppm) Microbials Complies with ISO 11930 Shelf Life 2 years (room temp, sealed) 💡 Why Choose DropBrigt® HEPES? Beyond buffering, this "smart" active: Rescues UV-stressed skin via melanin suppression. Boosts actives’ efficacy in serums, toners, and creams. Works synergistically with brightening powerhouses (vitamin C, tranexamic acid). Simplifies formulating with water solubility and process flexibility. "HEPES isn’t just a pH adjuster—it’s a force multiplier for radiant skin results."   Elevate brightening formulations with DropBrigt® HEPES—where science meets synergy. If you are interested in our products and want to know more details, please contact judyzhou@drop-bio.com.