A Biologically Active Functional Ingredient Derived From Hydrolyzed Marine DNA

DropCare® PDRN is a biologically active functional ingredient derived from hydrolyzed marine DNA (typically salmon milt), where sodium ions stabilize the phosphate backbone. It delivers gene-level skincare by activating cellular repair mechanisms and enhancing barrier function.

Key Bioactive Properties

1. DNA Damage Repair

Mechanism: Fragments bind to TLR9 receptors on keratinocytes, upregulating XPC/OGG1 DNA repair enzymes.

Efficacy: Reduces UV-induced thymine dimers by 62% (in vitro).

2. Cellular Energy Activation

Hydrolyzed nucleotides (deoxyadenosine/ deoxyguanosine) penetrate via follicular pathways, boosting ATP production by 150% (fibroblast assay).

3. Barrier Fortification

Forms electrostatic films that increase stratum corneum hydration (+23% corneometer value vs. hyaluronic acid).

4. Anti-Inflammatory Signaling

Suppresses NF-κB pathway, decreasing IL-6/TNF-α by 45-78% in sensitized skin.

Application: Photodamage Repair & Barrier Reinforcement & Cellular Revitalization & Anti-Inflammatory Care  

Dosage: 0.1-1.0%
 

Solubility: Easily soluble in water.

Storage: Store sealed at 2-8℃, away from wet and light. -20℃ for long time storage.

Shelf life: 2 years.

If you are interested in our products and want to know more details, please contact judyzhou@drop-bio.com.